Silence Therapeutics plc
SLN · NASDAQ Global Market · USD
19,75USD
+0,02 (+0,10 %)Stand 9. Nov., 21:00
Nachbörslich19,750,00 (0,00 %)17:48 ET
Kennzahlen
- Eröffnung
- 19,71
- Vortag
- 19,73
- Tagesspanne
- 19,70 – 19,76
- 52 Wochen
- 4,19 – 19,87
- Volumen
- 1,38 Mio.
- Ø Volumen
- 2,15 Mio.
- Börsenwert
- 932,87 Mio. $
- KGV
- -5,2
- Gewinn je Aktie (TTM)
- -3,81
- Dividendenrendite
- 0,0 %
- Beta
- 1,3
- Nächste Zahlen
- –
Finanzen
| USD | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 |
|---|---|---|---|---|---|
| Umsatz | 559.000 | 43,26 Mio. | 25,38 Mio. | 17,65 Mio. | 12,42 Mio. |
| Herstellungskosten | 215.000 | 11,81 Mio. | 10,32 Mio. | 10,97 Mio. | 7,46 Mio. |
| Bruttogewinn | 344.000 | 31,45 Mio. | 15,06 Mio. | 6,68 Mio. | 4,96 Mio. |
| Forschung und Entwicklung | 67,75 Mio. | 67,88 Mio. | 44,03 Mio. | 35,5 Mio. | 30,77 Mio. |
| Vertrieb und Verwaltung | 22,34 Mio. | 26,88 Mio. | 20,64 Mio. | 20,94 Mio. | 20,01 Mio. |
| Operatives Ergebnis | −89,75 Mio. | −63,32 Mio. | −49,6 Mio. | −49,76 Mio. | −45,81 Mio. |
| EBITDA | −88,05 Mio. | −49,12 Mio. | −49,78 Mio. | −39,93 Mio. | −45,42 Mio. |
| Nettogewinn | −88,61 Mio. | −45,31 Mio. | −43,27 Mio. | −41,03 Mio. | −39,41 Mio. |
| Gewinn je Aktie (verwässert) | -5,67 | -2,37 | -3,48 | -3,78 | -1,35 |
Umsatz nach Segment
Produkte · FY 2025
- Research Collaboration Income559.000 £100,00 %−98,70 %
Anteil · ggü. Vorjahr (FY 2024)
Regionen · FY 2024
- GERMANY144.000 £100,00 %−74,69 %
Anteil · ggü. Vorjahr (FY 2023)
Bewertung
Letzte 12 Monate
- KGV
- -5,2
- Kurs-Umsatz-Verhältnis
- 1.518,6
- Kurs-Buchwert-Verhältnis
- 8,1
- PEG
- -0,4
- Bruttomarge
- 51,0 %
- Operative Marge
- −10.880,2 %
- Nettomarge
- −9.759,2 %
- Verschuldungsgrad
- 0,0
- EV/EBITDA
- -14,3
- Eigenkapitalrendite
- −106,9 %
- Kapitalrendite (ROIC)
- −71,3 %
- Free-Cashflow-Rendite
- −4,5 %
| FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | |
|---|---|---|---|---|---|
| Bruttomarge | 61,5 % | 72,7 % | 59,3 % | 37,8 % | 39,9 % |
| Operative Marge | −16.056,0 % | −146,4 % | −195,5 % | −281,9 % | −369,0 % |
| Nettomarge | −15.851,9 % | −104,7 % | −170,5 % | −232,4 % | −317,4 % |
| KGV | -1,1 | -2,3 | -3,9 | -3,3 | -13,1 |
| Kurs-Umsatz-Verhältnis | 171,2 | 2,0 | 6,7 | 7,7 | 42,2 |
| Kurs-Buchwert-Verhältnis | 1,5 | 0,8 | 7,7 | 6,1 | 61,4 |
| Verschuldungsgrad | 0,0 | 0,0 | 0,0 | 0,0 | 0,0 |
| Liquidität 3. Grades | 8,7 | 11,1 | 4,6 | 4,4 | 5,7 |
| Dividendenrendite | 0,0 % | 0,0 % | 0,0 % | 0,0 % | 0,0 % |
| Unternehmenswert | 84,61 Mio. | −12,06 Mio. | 114,71 Mio. | 80,92 Mio. | 449,95 Mio. |
| EV/EBITDA | -1,0 | 0,2 | -2,3 | -2,0 | -9,9 |
| Eigenkapitalrendite | −142,2 % | −42,3 % | −196,7 % | −185,9 % | −462,2 % |
| Kapitalrendite (ROIC) | −76,1 % | −42,6 % | −55,4 % | −57,9 % | −48,5 % |
| Free-Cashflow-Rendite | −65,1 % | −64,0 % | −23,3 % | −42,6 % | 1,4 % |
Wachstum
| FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | |
|---|---|---|---|---|---|
| Umsatz | −98,7 % | +70,5 % | +43,7 % | +42,2 % | +126,6 % |
| Bruttogewinn | −98,9 % | +108,9 % | +125,5 % | +34,7 % | +188,8 % |
| Operatives Ergebnis | −41,7 % | −27,6 % | +0,3 % | −8,6 % | −27,8 % |
| Nettogewinn | −95,6 % | −4,7 % | −5,4 % | −4,1 % | −21,1 % |
| Gewinn je Aktie | −139,2 % | +31,9 % | +7,9 % | −180,0 % | −21,6 % |
| Freier Cashflow | −15,0 % | −37,6 % | +31,6 % | −879,8 % | +165,4 % |
| Dividende je Aktie | 0,0 % | 0,0 % | 0,0 % | 0,0 % | 0,0 % |
Analysten
Einstufungen · Buy
- 0Stark kaufen
- 3Kaufen
- 1Halten
- 1Verkaufen
- 0Stark verkaufen
Kursziel
20,00
Durchschnitt · +1,27 %
Schätzungen
| FY 2026 | FY 2027 | FY 2028 | |
|---|---|---|---|
| Umsatz (Ø) | 438.143 | 1,26 Mio. | 713.564 |
| Umsatz (Tief – Hoch) | 427.456 – 448.829 | 171.765 – 2,34 Mio. | 205.304 – 1,24 Mio. |
| Gewinn je Aktie (Ø) | -0,37 | -0,55 | -0,66 |
| Gewinn je Aktie (Tief – Hoch) | -0,51 – -0,16 | -0,81 – -0,22 | -1,30 – -0,05 |
| Analysten | 3 | 3 | 1 |
Letzte Änderungen
- HC Wainwright & Co.21. Okt. 2026Buy → Neutral
- Morgan Stanley11. Aug. 2026Overweight
- HC Wainwright & Co.17. Juni 2026Buy
- HC Wainwright & Co.13. März 2026Buy
- HC Wainwright & Co.16. Sept. 2025Buy
- Chardan Capital8. Aug. 2025Buy
- HC Wainwright & Co.13. Juni 2025Buy
- Chardan Capital13. Juni 2025Buy
Quartalszahlen
| Aug. 2026 | Mai 2026 | März 2026 | Nov. 2025 | Aug. 2025 | Mai 2025 | Feb. 2025 | Nov. 2024 | |
|---|---|---|---|---|---|---|---|---|
| Gewinn je Aktie · Erwartet | -0,14 | -0,33 | -0,32 | -0,40 | -0,27 | -0,18 | -0,45 | -0,42 |
| Gewinn je Aktie · Tatsächlich | -0,26 | -0,32 | -0,25 | -0,45 | -0,54 | -0,60 | 0,27 | -0,75 |
| Abweichung | −87,51 % | +3,03 % | +21,88 % | −12,50 % | −100,00 % | −233,33 % | +160,00 % | −78,57 % |
| Umsatz · Tatsächlich | 137.150 | 422.000 | 39.000 | 159.000 | 224.000 | 142.000 | 25,08 Mio. | 1,45 Mio. |
Dividenden und Splits
Keine Dividenden gezahlt.
Aktiensplits
–
Eigentümer
Institutionen
Q2 2026 · 13F
- Anteil institutioneller Investoren
- 141,23 %
- Investoren mit 13F-Meldung
- 76
Größte Investoren
- SIREN, L.L.C.21,03 %3,31 Mio.
- TCG CROSSOVER MANAGEMENT, LLC19,27 %3,03 Mio.
- REDMILE GROUP, LLC13,75 %2,16 Mio.
- NANTAHALA CAPITAL MANAGEMENT, LLC8,55 %1,35 Mio.
- CITADEL ADVISORS LLC8,44 %1,33 Mio.
- NEXTECH INVEST LTD.6,05 %952.400
- MILLENNIUM MANAGEMENT LLC5,77 %909.279
- IKARIAN CAPITAL, LLC5,28 %830.784
Insider-Geschäfte
- Griffiths Richard Ian10. Aug. 2026 · 10 percent ownerKauf2,79 Mio. Aktien · 16,00
- Griffiths Richard Ian10. Aug. 2026 · 10 percent ownerKauf100.000 Aktien · 15,58
- Griffiths Richard Ian10. Aug. 2026 · 10 percent ownerKauf50.000 Aktien · 16,09
- Griffiths Richard Ian10. Aug. 2026 · 10 percent ownerKauf3500 Aktien · 16,35
- Griffiths Richard Ian10. Aug. 2026 · 10 percent ownerKauf800.000 Aktien · 16,00
- Griffiths Richard Ian10. Aug. 2026 · 10 percent ownerKauf382.000 Aktien · 16,00
- Griffiths Richard Ian10. Aug. 2026 · 10 percent ownerKauf470.820 Aktien · 16,09
- Griffiths Richard Ian10. Aug. 2026 · 10 percent ownerKauf605.174 Aktien · 16,00
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Über das Unternehmen
Silence Therapeutics plc is a London, UK-based biotechnology company specializing in the research and development of groundbreaking ribonucleic acid (RNA) therapeutics. Its therapeutic focus areas include hematological, cardiovascular, and various rare and metabolic conditions. Central to their innovative approach is the mRNAi GalNAc Oligonucleotide Discovery platform, which is designed for precise targeting of specific disease-causing genes within the liver. The company's methodology harnesses the body's natural RNA interference (RNAi) mechanism by designing short interfering RNA (siRNA) molecules that degrade messenger RNA (mRNA), thereby preventing the production of targeted disease-associated proteins. Their pipeline features several promising candidates, including SLN360, currently in Phase I clinical trials for cardiovascular disease associated with elevated lipoprotein. Another key candidate, SLN124, is undergoing Phase I clinical trials for non-transfusion-dependent thalassemia and myelodysplastic syndrome, with further development planned for polycythemia vera. Silence Therapeutics also engages in strategic collaborations to expand its reach. It has agreements with AstraZeneca PLC to discover, develop, and commercialize siRNA therapeutics for cardiovascular, renal, metabolic, and respiratory diseases. Furthermore, a partnership with Mallinckrodt Pharma IP Trading DAC aims to develop and commercialize RNAi drug targets designed to silence the complement cascade in complement-mediated disorders. The company is also collaborating with Hansoh Pharmaceutical Group Company Limited to develop siRNAs for three unspecified targets, utilizing Silence's mRNAi GOLD platform. Originally incorporated as SR Pharma plc, the company rebranded to Silence Therapeutics plc in May 2007.
Führung
- Steven J. RomanoExecutive Vice President and Chief Research & Development Officer
- Rhonda L. HellumsExecutive VP, CFO, Secretary & Executive Director
- Iain Gladstone RossInterim CEO & Chairman of the Board
- Marie Wikstrom LindholmChief Scientific Officer
- Curtis RambaranChief Medical Officer
- Jaimin ShahSVP & General Counsel
- CEO
- Iain Gladstone Ross
- Mitarbeitende
- 88
- Hauptsitz
- London, GL, GB
- Sektor
- Healthcare
- Branche
- Biotechnology
- Börsengang
- 8. Sept. 2020
- Website
- silence-therapeutics.com
Nachrichten
- Business Wire · 4. Nov., 9:00Silence Therapeutics Announces Oral Presentation on SANRECO Phase 2 Study of Divesiran in Polycythemia Vera at ASH 2026
- Business Wire · 21. Okt., 15:35Silence Therapeutics Investor Alert: Kahn Swick & Foti, LLC Investigates Adequacy of Price and Process in Proposed Sale of Silence Therapeutics plc - SLN
- GuruFocus · 20. Okt., 13:00Are BRZE, SLN, OPCH, RXO Obtaining Fair Deals for their Shareholders?
- Zacks Investment Research · 20. Okt., 10:56Does Silence Therapeutics (SLN) Have the Potential to Rally 82.84% as Wall Street Analysts Expect?
- GlobeNewsWire · 20. Okt., 8:03BRODSKY & SMITH SHAREHOLDER UPDATE: Notifying Investors of the Following Investigations: Silence Therapeutics plc (Nasdaq – SLN), Option Care Health, Inc. (Nasdaq – OPCH), RXO Inc. (NYSE – RXO), Sangoma Technologies Corporation (Nasdaq – SANG)
- Proactive Investors · 19. Okt., 11:50Silence Therapeutics jumps 59% on Merck takeover
- Benzinga · 19. Okt., 10:05Silence Therapeutics, Disc Medicine, Veradermics And Other Big Stocks Moving Higher On Monday
- Business Wire · 19. Okt., 9:40SLN Stock Alert: Halper Sadeh LLC is Investigating Whether Silence Therapeutics plc is Obtaining a Fair Price for its Shareholders
- WSJ · 19. Okt., 8:48Germany's Merck to Buy U.K. Biotech Silence Therapeutics for $1.3 Billion
- Business Wire · 19. Okt., 8:00Merck KGaA, Darmstadt, Germany to Acquire Silence Therapeutics, Strengthening Rare Disease Pipeline with Innovative siRNA Asset
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